Immunoreactivity of CD99 in Non-Hodgkin's Lymphoma: Unexpected Frequent Expression in ALK-positive Anaplastic Large Cell Lymphoma

Immunoreactivity of CD99 in Non-Hodgkin's Lymphoma: Unexpected Frequent Expression in ALK-positive Anaplastic Large Cell Lymphoma

To verify the spectrum of CD99-expressing lymphoid malignancy, an immunohistochemical study for CD99 was carried out in 182 cases of non-Hodgkin's lymphoma, including 21 lymphoblastic lymphomas, 11 small lymphocytic lymphomas, 9 mantle cell lymphomas, 12 follicular lymphomas, 37 diffuse large B cell lymphomas, 18 Burkitt's lymphomas, 28 NK/T-cell lymphomas, 8 angioimmunoblastic T-cell lymphomas...

ALK- negative Anaplastic Large Cell Lymphoma of Bone

Small cell variant of anaplastic large cell lymphoma with positive immunoreactivity for CD99.

A 13 year old boy presented with a huge mass on his right arm of 6 months duration. Histopathological examination revealed sheets of malignant small round blue cells with immunopositivity for LCA, CD43, CD45Ro, CD30, EMA, ALK-1 and CD99, and negativity for CD20, TdT, myogenin, myoD1, NSE, bcl-6, bcl-2 and CD10. Fluorescent In-Situ Hybridization (FISH) testing excluded the diagnosis of Ewing's s...

Leukemic phase of ALK-positive anaplastic large cell lymphoma.

A 25-year-old woman presented with lymphadenopathy. Peripheral blood showed leukocytosis, anemia, and thrombocytopenia (white blood cell count, 102.9 3 10/L; hemoglobin level, 76 g/L; and platelet count, 32 3 10/L). Peripheral smear demonstrated a predominant population of large cells with reticular chromatin, folded to irregular nuclear contours, and abundant basophilic cytoplasm. Many cells c...

MicroRNA and ALK-positive anaplastic large cell lymphoma.

In this review we describe the current literature covering the role of microRNA in anaplastic large cell lymphoma (ALCL). MicroRNA is one of the best characterized subgroups of non-coding RNAs and it is now becoming clear that its importance in oncogenesis has been greatly underestimated. In ALCL the deregulation of a diverse range of microRNA has been demonstrated however much less is known ab...